PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Related Products (4114)
Related Products (4114)
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PROTAC Linkers Isoform Comparison
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(S,E)-Cyclooct-2-enol
0 ImagesCat. No.: HY-24592CAS No.: 93301-76-9(S,E)-Cyclooct-2-enol is a Click Amino Acid that can be used as a linker in the synthesis of PROTAC molecules. TCO-NHS ester contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing a Tetrazine group.
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N3-C5-O-C-Boc
0 ImagesCat. No.: HY-161792CAS No.: 2836521-02-7
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Benzyl 5-Bromopentanoate
0 ImagesCat. No.: HY-W674673CAS No.: 60343-28-4
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Benzyl 4-(4-((Tert-butoxycarbonyl)amino)butyl)piperazine-1-carboxylate
0 ImagesCat. No.: HY-W674500CAS No.: 877664-86-3
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(Rac)-Biotin-PEG3-oxyamine hydrochloride
0 ImagesCat. No.: HY-140938ACAS No.: 2823942-01-2
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m-PEG16-NH2
0 ImagesCat. No.: HY-133288CAS No.: 907577-50-8
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BocNH-PEG2-CH2CH2NHMe
0 ImagesCat. No.: HY-W876255CAS No.: 880359-74-0
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tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate hydrochloride
![tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate hydrochloride](https://file.medchemexpress.com/product_pic/hy-30754.gif "Click to View tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate hydrochloride Product Detail")
0 ImagesCat. No.: HY-30754CAS No.: 929302-18-1
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11-Cyanoundecanoic acid
0 ImagesCat. No.: HY-W354597CAS No.: 5810-18-4
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2-(4-Chlorophenyl)ethanol
0 ImagesCat. No.: HY-W001946CAS No.: 1875-88-3
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2-((1-(tert-Butoxycarbonyl)azetidin-3-yl)oxy)acetic acid
0 ImagesCat. No.: HY-20967CAS No.: 889952-83-4
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Tert-butyl 4-(4-(aminomethyl)benzyl)piperazine-1-carboxylate
0 ImagesCat. No.: HY-W424242CAS No.: 1415109-59-9
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2-Boc-2-Azaspiro[3.3]heptane-6-carbonitrile
![2-Boc-2-Azaspiro[3.3]heptane-6-carbonitrile](https://file.medchemexpress.com/product_pic/hy-w394962.gif "Click to View 2-Boc-2-Azaspiro[3.3]heptane-6-carbonitrile Product Detail")
0 ImagesCat. No.: HY-W394962CAS No.: 1374658-94-2
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Tert-butyl 4-(cyanomethyl)piperazine-1-carboxylate
0 ImagesCat. No.: HY-W046507CAS No.: 77290-31-4
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Methyl 7-aminoheptanoate
0 ImagesCat. No.: HY-W354114CAS No.: 39979-08-3
